Reproducibility will not cure what ails science

What Will It Take to Cure HIV?

Investigational strategies to attempt HIV cure or remission include very early initiation of antiretroviral therapy to limit the latent HIV reservoir and preinfection vaccination. In the setting of viral suppression, strategies include reactivation of latently infected cells (eg, through "shock" therapy with histone deacetylase inhibitors or other agents); use of broadly neutralizing antibodies...

What ails health care

Preventing suicide: what will work and what will not.

What Ails the Present Medical Care?

In spite of the vast amount of medical data at our disposal, there are limitations and drawbacks of medical care. This is due to the defective medical knowledge - the restricted narrow concepts of human being, illness, etiology and treatment. This has resulted in undue emphasis on physical aspect of human existence ignoring the mental and spiritual aspects in understanding the illness and treat...

Getting Rid of What Ails Us

DIAL (dihedral alignment) is a web server that provides public access to a new dynamic programming algorithm for pairwise 3D structural alignment of RNA. DIAL achieves quadratic time by performing an alignment that accounts for (i) pseudo-dihedral and/or dihedral angle similarity, (ii) nucleotide sequence similarity and (iii) nucleotide base-pairing